Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus.

@article{Shors1989InescapableVE,
  title={Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus.},
  author={Tracey J. Shors and Thomas Seib and Seymour Levine and Richard F. Thompson},
  journal={Science},
  year={1989},
  volume={244 4901},
  pages={224-6}
}
A group of rats was trained to escape low-intensity shock in a shuttle-box test, while another group of yoked controls could not escape but was exposed to the same amount and regime of shock. After 1 week of training, long-term potentiation (LTP) was measured in vitro in hippocampal slices. Exposure to uncontrollable shock massively impaired LTP relative to exposure to the same amount and regime of controllable shock. These results provide evidence that controllability modulates plasticity at… CONTINUE READING
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