Inertial sizing of aerosol inhaled from two dry powder inhalers with realistic breath patterns versus constant flow rates.

@article{Finlay2000InertialSO,
  title={Inertial sizing of aerosol inhaled from two dry powder inhalers with realistic breath patterns versus constant flow rates.},
  author={Warren H. Finlay and M G Gehmlich},
  journal={International journal of pharmaceutics},
  year={2000},
  volume={210 1-2},
  pages={83-95}
}
A procedure is developed that allows particles inhaled with realistic breath patterns to be sized by cascade impaction at a constant flow rate. This procedure is then used to examine the difference between particle sizes obtained with constant flow rate (step profile) versus actual-subject breath patterns for two dry powder inhalers DPIs: the Ventodisk and Spiros inhalers (delivering salbutamol sulphate). Aerosol inhaled from the DPIs by a breath simulator was combined with make-up air to… CONTINUE READING
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