Inertial cavitation dose and hemolysis produced in vitro with or without Optison.

@article{Chen2003InertialCD,
  title={Inertial cavitation dose and hemolysis produced in vitro with or without Optison.},
  author={Wen-shiang Chen and Andrew A. Brayman and Thomas J. Matula and Lawrence A. Crum},
  journal={Ultrasound in medicine & biology},
  year={2003},
  volume={29 5},
  pages={725-37}
}
Gas-based contrast agents (CAs) increase ultrasound (US)-induced bioeffects, presumably via an inertial cavitation (IC) mechanism. The relationship between IC dose (ICD) (cumulated root mean squared [RMS] broadband noise amplitude; frequency domain) and 1.1-MHz US-induced hemolysis in whole human blood was explored with Optison; the hypothesis was that hemolysis would correlate with ICD. Four experimental series were conducted, with variable: 1. peak negative acoustic pressure (P-), 2. Optison… CONTINUE READING

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