Inefficient response of T lymphocytes to glycosylphosphatidylinositol anchor-negative cells: implications for paroxysmal nocturnal hemoglobinuria.

@article{Murakami2002InefficientRO,
  title={Inefficient response of T lymphocytes to glycosylphosphatidylinositol anchor-negative cells: implications for paroxysmal nocturnal hemoglobinuria.},
  author={Yoshiko Murakami and Hiroshi Kosaka and Yusuke Maeda and Jun-ichi Nishimura and Norimitsu Inoue and Kazuhito Ohishi and Masaru Okabe and J. Takahashi Takeda and Taroh Kinoshita},
  journal={Blood},
  year={2002},
  volume={100 12},
  pages={4116-22}
}
Paroxysmal nocturnal hemoglobinuria (PNH) is a hematopoietic stem cell disorder in which clonal cells defective in glycosylphosphatidylinositol (GPI) biosynthesis are expanded, leading to complement-mediated hemolysis. PNH is often associated with bone marrow suppressive conditions, such as aplastic anemia. One hypothetical mechanism for the clonal expansion of GPI(-) cells in PNH is that the mutant cells escape attack by autoreactive cytotoxic cells that are thought to be responsible for… CONTINUE READING

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Different roles of glycosylphosphatidylinositol in various hematopoietic cells as RESPONSE OF T CELLS TO GPI ANCHOR – NEGATIVE CELLS

  • Y Murakami, T Kinoshita, Y Maeda, T Nakano, J Takeda
  • 2002

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