Inefficient human immunodeficiency virus replication in mobile lymphocytes.

  title={Inefficient human immunodeficiency virus replication in mobile lymphocytes.},
  author={Marion Sourisseau and Nathalie Sol-Foulon and Françoise 3 Porrot and Fabien P Blanchet and Olivier Schwartz},
  journal={Journal of virology},
  volume={81 2},
Cell-to-cell viral transfer facilitates the spread of lymphotropic retroviruses such as human immunodeficiency virus (HIV) and human T-cell leukemia virus (HTLV), likely through the formation of "virological synapses" between donor and target cells. Regarding HIV replication, the importance of cell contacts has been demonstrated, but this phenomenon remains only partly characterized. In order to alter cell-to-cell HIV transmission, we have maintained cultures under continuous gentle shaking and… CONTINUE READING
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