Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players

@article{Kruse2010InefficientCO,
  title={Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players},
  author={Kristin L. Kruse and C. Janko and V. Urbonaviciute and C. Mierke and T. Winkler and R. Voll and G. Schett and L. Munoz and M. Herrmann},
  journal={Apoptosis},
  year={2010},
  volume={15},
  pages={1098-1113}
}
Systemic lupus erythematosus (SLE) is a complex disease resulting from inflammatory responses of the immune system against several autoantigens. Inflammation is conditioned by the continuous presence of autoantibodies and leaked autoantigens, e.g. from not properly cleared dying and dead cells. Various soluble molecules and biophysical properties of the surface of apoptotic cells play significant roles in the appropriate recognition and further processing of dying and dead cells. We exemplarily… Expand
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