Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players

@article{Kruse2010InefficientCO,
  title={Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players},
  author={Kristin Kruse and Christina Janko and Vilma Urbonaviciute and Claudia Tanja Mierke and Thomas H. Winkler and Reinhard Edmund Voll and Georg Schett and Luis Enrique Munoz and Martin Herrmann},
  journal={Apoptosis},
  year={2010},
  volume={15},
  pages={1098-1113}
}
Systemic lupus erythematosus (SLE) is a complex disease resulting from inflammatory responses of the immune system against several autoantigens. Inflammation is conditioned by the continuous presence of autoantibodies and leaked autoantigens, e.g. from not properly cleared dying and dead cells. Various soluble molecules and biophysical properties of the surface of apoptotic cells play significant roles in the appropriate recognition and further processing of dying and dead cells. We exemplarily… CONTINUE READING