Inefficient Crossover Maturation Underlies Elevated Aneuploidy in Human Female Meiosis

@article{Wang2017InefficientCM,
  title={Inefficient Crossover Maturation Underlies Elevated Aneuploidy in Human Female Meiosis},
  author={Shunxin Wang and Terry J. Hassold and Patricia R Hunt and Martin A. White and D. Zickler and Nancy Kleckner and Liangran Zhang},
  journal={Cell},
  year={2017},
  volume={168},
  pages={977-989.e17}
}
Meiosis is the cellular program that underlies gamete formation. For this program, crossovers between homologous chromosomes play an essential mechanical role to ensure regular segregation. We present a detailed study of crossover formation in human male and female meiosis, enabled by modeling analysis. Results suggest that recombination in the two sexes proceeds analogously and efficiently through most stages. However, specifically in female (but not male), ∼25% of the intermediates that… CONTINUE READING
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