Ineffectiveness of colchicine for the prevention of restenosis after coronary angioplasty.

@article{OKeefe1992IneffectivenessOC,
  title={Ineffectiveness of colchicine for the prevention of restenosis after coronary angioplasty.},
  author={James H O'Keefe and Ben D. McCallister and Timothy M. Bateman and D L Kuhnlein and Robert W. Ligon and G O Hartzler},
  journal={Journal of the American College of Cardiology},
  year={1992},
  volume={19 7},
  pages={1597-600}
}
Colchicine, an antimitogenic agent, has shown promise in preventing restenosis after coronary angioplasty in experimental animal models. A prospective trial was conducted involving 197 patients randomized in a 2:1 fashion to treatment with oral colchicine, 0.6 mg twice daily (130 patients), or placebo (67 patients) for 6 months after elective coronary angioplasty. Treatment in all patients began between 12 h before angioplasty and 24 h after angioplasty. Compliance monitoring revealed that 96… CONTINUE READING
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