Industry Sponsorship and Authorship of Clinical Trials Over 20 Years

@article{Buchkowsky2004IndustrySA,
  title={Industry Sponsorship and Authorship of Clinical Trials Over 20 Years},
  author={Susan S Buchkowsky and Peter J. Jewesson},
  journal={Annals of Pharmacotherapy},
  year={2004},
  volume={38},
  pages={579 - 585}
}
BACKGROUND The pharmaceutical industry has become a major source of funding for biomedical research. Our general observation is that pharmaceutical industry employees are appearing with increasing frequency as coauthors of clinical trial publications. OBJECTIVE To characterize clinical trial funding, reporting, and sources; investigate author—industry affiliation; and describe clinical outcome trends over time. METHODS We reviewed 500 randomly selected clinical trials published in 5 influential… 
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114 Citations
Highly Influential Citations
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27
Results Citations
3

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References

SHOWING 1-10 OF 20 REFERENCES
Pharmaceutical industry sponsorship and research outcome and quality: systematic review
TLDR
Investigating whether funding of drug studies by the pharmaceutical industry is associated with outcomes that are favourable to the funder and whether the methods of trials funded by pharmaceutical companies differ from the methods in trials with other sources of support found systematic bias favours products which are made by the company funding the research.
Source of funding and outcome of clinical trials
  • R. Davidson
  • Medicine, Psychology
    Journal of general internal medicine
  • 1986
TLDR
Few trials supported by pharmaceutical manufacturers favored traditional therapy; some reasons for this finding may include selection of drugs likely to be proven efficacious, Type II errors (false-negative studies), and fear of discontinuation of funding should such studies be submitted.
Scope and impact of financial conflicts of interest in biomedical research: a systematic review.
TLDR
Original, quantitative studies on the extent, impact, and management of financial conflicts of interest in biomedical research are reviewed to show a statistically significant association between industry sponsorship and pro-industry conclusions.
Managing conflicts of interest in the conduct of clinical trials.
TLDR
To preserve the integrity ofResearch and to protect the welfare of human subjects who enroll in trials, physicians should have adequate training in the conduct of research and be familiar with the ethics of research.
The uncertainty principle and industry-sponsored research
Publication bias and clinical trials.
Funding source, trial outcome and reporting quality: are they related? Results of a pilot study
TLDR
It is not known whether the absence of significant associations between funding source, trial outcome and reporting quality reflects a true absence of an association or is an artefact of inadequate statistical power, reliance on voluntary disclosure of funding information, a focus on trials recently published in the top medical journals, or some combination thereof.
Bias in reporting clinical trials.
  • A. Bardy
  • Medicine
    British journal of clinical pharmacology
  • 1998
TLDR
Substantial evidence of selective reporting was detected, since trials with positive outcome resulted more often in submission of final report to regulatory authority than those with inconclusive or negative outcomes.
Pharmaceutical advertising revenue and physician organizations: how much is too much?
TLDR
Potential financial conflicts of interest arising from pharmaceutical advertisements in medical journals may be substantial and the impact on professional societies' financial independence and behavior is unknown.
Uneasy alliance--clinical investigators and the pharmaceutical industry.
TLDR
The past 10 years have seen the spectacular growth of a new research model, and commercially oriented networks of contract-research organizations (CROs) and site-management organizations (SMOs) have altered.
...
...