Industrial production of recombinant therapeutics in Escherichia coli and its recent advancements

@article{Huang2011IndustrialPO,
  title={Industrial production of recombinant therapeutics in Escherichia coli and its recent advancements},
  author={Chung-Jr Huang and H. Lin and X. Yang},
  journal={Journal of Industrial Microbiology & Biotechnology},
  year={2011},
  volume={39},
  pages={383-399}
}
Nearly 30% of currently approved recombinant therapeutic proteins are produced in Escherichia coli. Due to its well-characterized genetics, rapid growth and high-yield production, E. coli has been a preferred choice and a workhorse for expression of non-glycosylated proteins in the biotech industry. There is a wealth of knowledge and comprehensive tools for E. coli systems, such as expression vectors, production strains, protein folding and fermentation technologies, that are well tailored for… Expand
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