Industrial biocatalysis today and tomorrow

  title={Industrial biocatalysis today and tomorrow},
  author={Andrew Schmid and Jonathan S. Dordick and Bernhard Hauer and Andreas Kiener and Marcel G. Wubbolts and Bernard Witholt},
The use of biocatalysis for industrial synthetic chemistry is on the verge of significant growth. Biocatalytic processes can now be carried out in organic solvents as well as aqueous environments, so that apolar organic compounds as well as water-soluble compounds can be modified selectively and efficiently with enzymes and biocatalytically active cells. As the use of biocatalysis for industrial chemical synthesis becomes easier, several chemical companies have begun to increase significantly… Expand
Biocatalysis explained: from pharmaceutical to bulk chemical production
Biocatalysis is one of the most promising technologies for the sustainable synthesis of molecules for pharmaceutical, biotechnological and industrial purposes. From the gram to the ton scale,Expand
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A review of biocatalysis with a special focus on scalable chemical production using enzymes discusses the opportunities and limitations of enzymatic syntheses using distinct examples and provides an outlook on emerging enzyme classes. Expand
Dispelling the Myths--Biocatalysis in Industrial Synthesis
Expect many new industrial applications of biocatalysis to be realized, from single-step enzymatic conversions to customized multistep microbial synthesis by means of metabolic pathway engineering. Expand
Potential of Biocatalysis in Pharmaceuticals
Biocatalysis has been continuously evolving as an essential tool which is playing a significant role in the industrial synthesis of chemicals, active pharmaceuticals, pharmaceutical intermediates,Expand
Biocatalysis in the Pharmaceutical Industry: The Need for Speed.
  • M. Truppo
  • Engineering, Medicine
  • ACS medicinal chemistry letters
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Dramatic increases in the speed of protein engineering are needed to deliver on the ever increasing opportunities for industrial biocatalytic processes. Expand
Biocatalysis with enzymes immobilized on mesoporous hosts: the status quo and future trends
Biocatalysis opens the door to green and sustainable processes in synthetic chemistry, in the production of natural products, and in waste management. Furthermore, due to the often similar reactionExpand
Strategies for Improving Enzymes for Efficient Biocatalysis
Biocatalytic processes are finding increasingly widespread application not only in academia, but also in industry. This is particularly true in the pharmaceutical and agrochemical industries whereExpand
New generation of biocatalysts for organic synthesis.
The advantages and applications of the most recent and attractive biocatalysts--reductases, transaminases, ammonia lyases, epoxide hydrolases, and dehalogenases--will be discussed herein and exemplified by the syntheses of interesting compounds. Expand
Biotransformations in Pure Organic Medium: Organic Solvent‐Labile Enzymes in the Batch and Flow Synthesis of Nitriles
In recent years, there has been an increasing tendency to use biocatalysts in industrial chemistry, especially in the pharma and fine chemical sector. Preferably, enzymes or whole cells, applied asExpand
Applied biotransformations in green solvents.
Different attempts to combine the valuable properties of green solvents with the advantages of using biocatalysts for developing cleaner synthetic processes are focused on. Expand


Biocatalysis in the gas phase.
The biocatalysis of substrates in the gas phase may offer advantages over many conventional solution-based reactions, both in analytical devices and in bioreactors designed to accommodate this newExpand
Biotransformations in Organic Chemistry — A Textbook
The use of biocatalysts, employed either as isolated enzymes or whole cells, offer a remarkable arsenal of highly selective transformations for modern preparative organic chemistry. During the pastExpand
Biocatalytic combinatorial synthesis.
Combinatorial biocatalysis, based on a principle of the combinatorial use of biosynthetic steps rather than the combinating use of reagents, offers a complementary approach to combinatorials chemistry, which provides access to analogues not readily accessible by chemical synthetic means alone. Expand
Biocatalytic plastics as active and stable materials for biotransformations
The marriage of enzyme technology with polymer chemistry opens up an array of unique applications for plastic enzymes, including active and stable biocatalysts in paints, coatings, resins, foams, and beads, as well as membranes, fibers, and tubings. Expand
Chemical versus biochemical conversion: when and how to use biocatalysts.
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  • Chemistry, Medicine
  • Biotechnology and bioengineering
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A decision tree is introduced which provides important questions to answer to come to an optimal use of biocatalysts and examples are given to illustrate the decision making. Expand
Application of nitrite converting enzymes for the production of useful compounds
The chemical industry has recently begun to look at enzymes as novel catalysts for many organic syntheses. Nitrile-hydrolyzing enzymes such as nitrile hydratase and nitrilase have great potential asExpand
Biocatalysts for industry
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Biocatalytic Solvent‐Free Polymerization To Produce High Molecular Weight Polyesters
Environmentally benign chemical synthesis is a central thrust in the current U.S. research arena. Production of polymers contributes to pollution during synthesis and after use. Thus, the synthesisExpand
A direct electrode-driven P450 cycle for biocatalysis.
  • V. Reipa, M. Mayhew, V. Vilker
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
A bioreactor where the reducing power to the cycle is supplied directly to purified cytochrome CYP101 through its natural redox partner (putidaredoxin) using an antimony-doped tin oxide working electrode. Expand
Combinatorial biocatalysis: a natural approach to drug discovery.
Combinatorial biocatalysis is a powerful addition to the expanding array of combinatorial methods for the generation and optimization of lead compounds in drug discovery and development. Expand