Industrial biocatalysis today and tomorrow

  title={Industrial biocatalysis today and tomorrow},
  author={Andrew Schmid and Jonathan S. Dordick and Bernhard Hauer and Andreas Kiener and Marcel G. Wubbolts and Bernard Witholt},
The use of biocatalysis for industrial synthetic chemistry is on the verge of significant growth. Biocatalytic processes can now be carried out in organic solvents as well as aqueous environments, so that apolar organic compounds as well as water-soluble compounds can be modified selectively and efficiently with enzymes and biocatalytically active cells. As the use of biocatalysis for industrial chemical synthesis becomes easier, several chemical companies have begun to increase significantly… 

Biocatalysis: Enzymatic Synthesis for Industrial Applications

A review of biocatalysis with a special focus on scalable chemical production using enzymes discusses the opportunities and limitations of enzymatic syntheses using distinct examples and provides an outlook on emerging enzyme classes.

Dispelling the Myths--Biocatalysis in Industrial Synthesis

Expect many new industrial applications of biocatalysis to be realized, from single-step enzymatic conversions to customized multistep microbial synthesis by means of metabolic pathway engineering.

Potential of Biocatalysis in Pharmaceuticals

This chapter compile the broad applications of biocatalysts in the synthesis of pharmaceuticals, which include chemoenzymatic pathway and biological cascade reactions.

Biocatalysis in the Pharmaceutical Industry: The Need for Speed.

  • M. Truppo
  • Biology, Engineering
    ACS medicinal chemistry letters
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Dramatic increases in the speed of protein engineering are needed to deliver on the ever increasing opportunities for industrial biocatalytic processes.

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Whole organism biocatalysis.

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The advantages and applications of the most recent and attractive biocatalysts--reductases, transaminases, ammonia lyases, epoxide hydrolases, and dehalogenases--will be discussed herein and exemplified by the syntheses of interesting compounds.

Engineering the third wave of biocatalysis

Applications of protein-engineered biocatalysts ranging from commodity chemicals to advanced pharmaceutical intermediates that use enzyme catalysis as a key step are discussed.

Biotransformations in Pure Organic Medium: Organic Solvent‐Labile Enzymes in the Batch and Flow Synthesis of Nitriles

In recent years, there has been an increasing tendency to use biocatalysts in industrial chemistry, especially in the pharma and fine chemical sector, but a major problem is the insolubility of hydrophobic substrates in such aqueous reaction media.



Application of in situ product-removal techniques to biocatalytic processes.

Biocatalysis in the gas phase.

Biotransformations in Organic Chemistry — A Textbook

The use of biocatalysts, employed either as isolated enzymes or whole cells, offer a remarkable arsenal of highly selective transformations for modern preparative organic chemistry, and the different types of reactions are explained according to the "reaction principle".

Biocatalytic combinatorial synthesis.

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The marriage of enzyme technology with polymer chemistry opens up an array of unique applications for plastic enzymes, including active and stable biocatalysts in paints, coatings, resins, foams, and beads, as well as membranes, fibers, and tubings.

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  • Biology, Engineering
    Biotechnology and bioengineering
  • 1996
A decision tree is introduced which provides important questions to answer to come to an optimal use of biocatalysts and examples are given to illustrate the decision making.

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Biocatalytic Solvent‐Free Polymerization To Produce High Molecular Weight Polyesters

Environmentally benign chemical synthesis is a central thrust in the current U.S. research arena. Production of polymers contributes to pollution during synthesis and after use. Thus, the synthesis

Biocatalysis and Process Integration in the Synthesis of Semi-synthetic Antibiotics

Hydrolysis specific in and mod-eling of important features at the active site suggest critical attributes that can be further modified to continue the rational design of this enzyme for bioremediation of pesticide contaminants and CW A stock-piles.

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A bioreactor where the reducing power to the cycle is supplied directly to purified cytochrome CYP101 through its natural redox partner (putidaredoxin) using an antimony-doped tin oxide working electrode.