Inductively coupled plasma mass spectroscopy quantitation of platinum-DNA adducts in peripheral blood leukocytes of patients receiving cisplatin- or carboplatin-based chemotherapy.

@article{Bonetti1996InductivelyCP,
  title={Inductively coupled plasma mass spectroscopy quantitation of platinum-DNA adducts in peripheral blood leukocytes of patients receiving cisplatin- or carboplatin-based chemotherapy.},
  author={Andrea Bonetti and Piero Apostoli and M Zaninelli and Flavia Pavanel and Marco Colombatti and Gian Luigi Cetto and Tiziano Franceschi and Loris Sperotto and Roberto Leone},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1996},
  volume={2 11},
  pages={1829-35}
}
Platinum-DNA adducts can be assayed in peripheral blood leukocytes by means of atomic absorption spectroscopy and ELISA, and high adduct levels have been correlated previously with favorable clinical response to platinum-based chemotherapy. Our purpose was to study adduct formation in peripheral blood leukocytes by means of a new method, inductively coupled plasma mass spectroscopy (ICP-MS), and to correlate adduct formation with clinical response and toxicity. Platinum (Pt)-DNA adducts were… CONTINUE READING