Inductive Effects of Dexamethasone on the Gene Expression of Cbfa1, Osterix and Bone Matrix Proteins During Differentiation of Cultured Primary Rat Osteoblasts

@article{Igarashi2003InductiveEO,
  title={Inductive Effects of Dexamethasone on the Gene Expression of Cbfa1, Osterix and Bone Matrix Proteins During Differentiation of Cultured Primary Rat Osteoblasts},
  author={Masato Igarashi and Naoko Kamiya and Mitsuharu Hasegawa and Tomohiro Kasuya and Tomihisa Takahashi and Minoru Takagi},
  journal={Journal of Molecular Histology},
  year={2003},
  volume={35},
  pages={3-10}
}
Runx2/core binding factor alpha 1 (Cbfa1) and Osterix (Osx) are osteoblast-specific transcription factors essential for the development of a mature osteoblast phenotype and are thought to activate osteoblast marker genes in vivo to produce a bone-specific matrix. Dexamethasone (Dex) is known to be a potent stimulator of osteoblastic differentiation in vitro, however, the exact role is still unclear. To investigate the mechanisms of the stimulation of osteoblastic differentiation by Dex, we… CONTINUE READING
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