Inductive Effects of Dexamethasone on the Gene Expression of Cbfa1, Osterix and Bone Matrix Proteins During Differentiation of Cultured Primary Rat Osteoblasts

@article{Igarashi2004InductiveEO,
  title={Inductive Effects of Dexamethasone on the Gene Expression of Cbfa1, Osterix and Bone Matrix Proteins During Differentiation of Cultured Primary Rat Osteoblasts},
  author={M. Igarashi and Naoko Kamiya and M. Hasegawa and Tomohiro Kasuya and T. Takahashi and M. Takagi},
  journal={Journal of Molecular Histology},
  year={2004},
  volume={35},
  pages={3-10}
}
  • M. Igarashi, Naoko Kamiya, +3 authors M. Takagi
  • Published 2004
  • Biology, Medicine
  • Journal of Molecular Histology
  • Runx2/core binding factor alpha 1 (Cbfa1) and Osterix (Osx) are osteoblast-specific transcription factors essential for the development of a mature osteoblast phenotype and are thought to activate osteoblast marker genes in vivo to produce a bone-specific matrix. Dexamethasone (Dex) is known to be a potent stimulator of osteoblastic differentiation in vitro, however, the exact role is still unclear. To investigate the mechanisms of the stimulation of osteoblastic differentiation by Dex, we… CONTINUE READING

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    Publications referenced by this paper.
    SHOWING 1-10 OF 78 REFERENCES
    Dexamethasone induction of osteoblast mRNAs in rat marrow stromal cell cultures
    • 326