Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen.

@article{Robles1994InductionVP,
  title={Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen.},
  author={M T S{\'a}enz Robles and H S Symonds and Ji Di Chen and Terry Van Dyke},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 4},
  pages={2686-98}
}
The ability of simian virus 40-encoded large T antigen to disrupt the growth control of a variety of cell types is related to its ability to interfere with certain cellular proteins, such as p53 and the retinoblastoma susceptibility gene product (pRB). We have used wild-type and mutant forms of T antigen in transgenic mice to dissect the roles of pRB, p53, and other cellular proteins in tumorigenesis of different cell types. In this study, using a cell-specific promoter to target expression… CONTINUE READING
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