Induction therapy alters plasma fibrin clot properties in multiple myeloma patients: association with thromboembolic complications.

@article{Undas2015InductionTA,
  title={Induction therapy alters plasma fibrin clot properties in multiple myeloma patients: association with thromboembolic complications.},
  author={Anetta Undas and Lidia Zubkiewicz-Usnarska and Grzegorz Helbig and Dariusz Woszczyk and Justyna Kozińska and Anna Dmoszyńska and Jakub Dębski and Maria Podolak-Dawidziak and Kazimierz Kuliczkowski},
  journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis},
  year={2015},
  volume={26 6},
  pages={621-7}
}
Induction therapy in patients with multiple myeloma increases the risk of thromboembolism. We have recently shown that multiple myeloma patients tend to form denser fibrin clots displaying poor lysability. We investigated the effect of induction therapy on fibrin clot properties in multiple myeloma patients. Ex-vivo plasma fibrin clot permeability, turbidity, susceptibility to lysis, thrombin generation, factor VIII and fibrinolytic proteins were compared in 48 multiple myeloma patients prior… CONTINUE READING
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