Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA.


The induction of anti-influenza cytotoxic T lymphocytes (CTL) in vivo by immunizing mice with liposomes containing messenger RNA (mRNA) encoding the influenza virus nucleoprotein (NP) is described. NP mRNA, obtained by in vitro transcription, was encapsulated into simple cholesterol/phosphatidylcholine/phosphatidylserine liposomes by the detergent removal… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.