Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators.

@article{Subramanian2004InductionOV,
  title={Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators.},
  author={Sukanya V. Subramanian and John A. Polikandriotis and Robert J Kelm and Jason J. David and Charles G. Orosz and Arthur Roger Strauch},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 10},
  pages={
          4532-43
        }
}
The mouse vascular smooth muscle alpha-actin (SMA) gene enhancer is activated in fibroblasts by transforming growth factor beta1 (TGFbeta1), a potent mediator of myofibroblast differentiation and wound healing. The SMA enhancer contains tandem sites for the Sp1 transcriptional activator protein and Puralpha and beta repressor proteins. We have examined… CONTINUE READING