Induction of vascular endothelial growth factor receptor-3 mRNA in glial cells following focal cerebral ischemia in rats

  title={Induction of vascular endothelial growth factor receptor-3 mRNA in glial cells following focal cerebral ischemia in rats},
  author={Yoo-Jin Shin and Jeong-Sun Choi and Jae-Youn Choi and Yun Hou and Jungho Cha and Myung Hoon Chun and Mun Yong Lee},
  journal={Journal of Neuroimmunology},

Increased expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 after pilocarpine-induced status epilepticus in mice

The spatiotemporal expression of VEGF-C and VEGFR-3 can be upregulated in hippocampal astrocytes and microglia after pilocarpine-induced status epilepticus, providing basic information about VEGFs and VFRs expression patterns following acute seizures.

Upregulation of Vascular Endothelial Growth Factor Receptor-3 in the Spinal Cord of Lewis Rats with Experimental Autoimmune Encephalomyelitis

  • Jang-Mi ParkYoo-Jin Shin M. Lee
  • Biology
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 2013
Analysis of spatiotemporal expression of vascular endothelial growth factor receptor–3 in the spinal cord of Lewis rats with experimental autoimmune encephalomyelitis suggests that VEGFR-3 is involved in the recruitment of monocytic macrophages and in glial reactions during EAE.

Expression of Vascular Endothelial Growth Factor-C (VEGF-C) and Its Receptor (VEGFR-3) in the Glial Reaction Elicited by Human Mesenchymal Stem Cell Engraftment in the Normal Rat Brain

The characteristic time- and cell-dependent expression patterns for VEGF-C and VEGFR-3 within the engrafted brain tissue are demonstrated, suggesting that they may contribute to neuroinflammation in MSC transplantation, possibly through the recruitment and/or activation of microglia/macrophages and astrogliosis.

Vascular Protection by Angiotensin Receptor Antagonism Involves Differential VEGF Expression in Both Hemispheres after Experimental Stroke

Vascular restoration by candesartan after stroke maybe related to differential regional upregulation of VEGFB and VEGFA, promoting a “prosurvival state” in the ischemic hemisphere and angiogenesis in the contralesional side, respectively, which are likely to contribute to enhanced recovery after stroke.

Vascular endothelial growth factor receptor‐3 regulates astroglial glutamate transporter‐1 expression via mTOR activation in reactive astrocytes following pilocarpine‐induced status epilepticus

It is suggested that VEGFR‐3 upregulation in reactive astrocytes may play a role in preventing hyperexcitability induced by continued seizure activity during the subacute phase of epilepsy.

Endothelin‐1 increases the expression of VEGF‐R1/Flt‐1 receptors in rat cultured astrocytes through ETB receptors

The findings suggest that endothelin‐1 induces up‐regulation of VEGF‐R1 receptors in astrocytes, and potentiates V EGF signals in damaged nerve tissues.



Differential regulation of vascular endothelial growth factor-C and its receptor in the rat hippocampus following transient forebrain ischemia

The changes in the expression of vascular endothelial growth factor-C (VEGF-C) and its receptor, VEGFR-3, in the rat hippocampus following transient forebrain ischemia suggest that VEGF-C may be involved in glial reaction via paracrine or autocrine mechanisms in the ischemic brain and may carry out specific roles in adult hippocampal neurogenesis during isChemic insults.

VEGFR-3/Flt-4 mediates proliferation and chemotaxis in glial precursor cells

Contribution of macrophages to angiogenesis induced by vascular endothelial growth factor receptor-3-specific ligands.

The data suggest that VEGFR-3-specific signaling can induce new blood vessels, to which macrophages contribute a major role, and signify its potential as an additional therapeutic target to the existing VEGF-A/VEGFR-2 signaling-based antiangiogenesis strategies.

Increased Severity of Cerebral Ischemic Injury in Vascular Endothelial Growth Factor-B–Deficient Mice

Vascular endothelial growth factor-B protected cultured cerebral cortical neurons from hypoxic injury, suggesting that its protective action is mediated at least in part through a direct effect on neurons.

VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain

VEGF-C has a new, evolutionary conserved function as a growth factor selectively required by neural progenitor cells expressing its receptor VEGFR-3 in the central nervous system.

Gene expression for VEGF-A, VEGF-C, and their receptors in murine lymphocytes and macrophages

It is found that peritoneal macrophages, thymocytes, and lymph node cells constitutively expressed VEGF-A and VEGf-C mRNA, which suggests that, along with their major angiogenic properties, V EGF family members additionally might also perform important mediatory functions within the immune system.

Signalling via vascular endothelial growth factor receptor‐3 is sufficient for lymphangiogenesis in transgenic mice

It is demonstrated that stimulation of the VEGFR‐3 signal transduction pathway is sufficient to induce specifically lymphangiogenesis in vivo.