Induction of vanilloid receptor channel activity by protein kinase C

@article{Premkumar2000InductionOV,
  title={Induction of vanilloid receptor channel activity by protein kinase C},
  author={Louis S. Premkumar and Gerard Peter Ahern},
  journal={Nature},
  year={2000},
  volume={408},
  pages={985-990}
}
Capsaicin or vanilloid receptors (VRs) participate in the sensation of thermal and inflammatory pain. The cloned (VR1) and native VRs are non-selective cation channels directly activated by harmful heat, extracellular protons and vanilloid compounds. However, considerable attention has been focused on identifying other signalling pathways in VR activation; it is known that VR1 is also expressed in non-sensory tissue and may mediate inflammatory rather than acute thermal pain. Here we show that… CONTINUE READING
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