Induction of uncoupling protein-1 in mouse embryonic fibroblast-derived adipocytes by retinoic acid.

@article{Mercader2010InductionOU,
  title={Induction of uncoupling protein-1 in mouse embryonic fibroblast-derived adipocytes by retinoic acid.},
  author={Josep Maria Mercader and Catalina Pic{\'o} and Mª Luisa Bonet},
  journal={Obesity},
  year={2010},
  volume={18 4},
  pages={
          655-62
        }
}
The uncoupling protein-1 (UCP1) is the molecular effector of thermogenesis in brown adipocytes, a process in which there is a renewed interest after the recent recognition of its relevance in adult humans. Typical white adipocytes do not express UCP1. We investigated the capacity of retinoic acid (RA), the carboxylic acid form of vitamin A and a known positive regulator of UCP1 gene transcription in brown adipocytes, to stimulate UCP1 expression in adipocytes differentiated in culture from… CONTINUE READING
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