Induction of tyrosine phosphorylation during ICAM-3 and LFA-1-mediated intercellular adhesion, and its regulation by the CD45 tyrosine phosphatase

  title={Induction of tyrosine phosphorylation during ICAM-3 and LFA-1-mediated intercellular adhesion, and its regulation by the CD45 tyrosine phosphatase},
  author={Antonio Arroyo and Miguel R. Campanero and Paloma S{\'a}nchez-Mateos and Juan Marcelo Zapata and Mar{\'i}a Angeles Ursa and Miguel Angel Del Pozo and Francisco S{\'a}nchez-Madrid},
  journal={The Journal of Cell Biology},
  pages={1277 - 1286}
Intercellular adhesion molecule (ICAM)-3, a recently described counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin, appears to play an important role in the initial phase of immune response. We have previously described the involvement of ICAM-3 in the regulation of LFA-1/ICAM-1-dependent cell-cell interaction of T lymphoblasts. In this study, we further investigated the functional role of ICAM-3 in other leukocyte cell-cell interactions as well as the molecular… CONTINUE READING
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