Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases.

@article{Imbert1994InductionOT,
  title={Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases.},
  author={V{\'e}ronique Imbert and J. F. Peyron and D Farahi Far and Bernard Mari and Patrick Auberger and Bernard Rossi},
  journal={The Biochemical journal},
  year={1994},
  volume={297 ( Pt 1)},
  pages={163-73}
}
Rapid tyrosine phosphorylation of key cellular proteins is a crucial event in the transduction of activation signals to T-lymphocytes. The regulatory role of protein tyrosine phosphatases (PTPases) in this process was explored by studying the effects of a powerful PTPase inhibitor, vanadate peroxide (pervanadate), on the activation cascade of Jurkat human leukaemic T-cells. Pervanadate induced activation of the tyrosine kinases lck and fyn (4- and 3-fold respectively) and a dramatic increase in… CONTINUE READING

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