Induction of type-specific neutralizing antibodies by capsomeres of human papillomavirus type 33.

@article{Fligge2001InductionOT,
  title={Induction of type-specific neutralizing antibodies by capsomeres of human papillomavirus type 33.},
  author={Claudia Fligge and Tzenan Giroglou and Rolf E. Streeck and Martin Sapp},
  journal={Virology},
  year={2001},
  volume={283 2},
  pages={353-7}
}
The immunogenicity of capsomeres of human papillomavirus type 33 was evaluated in a dose-response analysis. Capsomeres were obtained free of capsids by expression of L1 carrying the single point mutation C427S. Neutralizing antibodies were detected using an in vitro pseudoinfection assay. Capsomeres induced type-specific, neutralizing antibodies in mice even in the absence of adjuvant. The neutralization titers of immune sera raised without adjuvant were 10- to 20-fold lower than those of… CONTINUE READING

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