Induction of type I interferons by a novel porcine reproductive and respiratory syndrome virus isolate.

@article{Nan2012InductionOT,
  title={Induction of type I interferons by a novel porcine reproductive and respiratory syndrome virus isolate.},
  author={Yuchen Nan and Rong Wang and Meiyan Shen and Kay S. Faaberg and Siba K Samal and Yanjin Zhang},
  journal={Virology},
  year={2012},
  volume={432 2},
  pages={261-70}
}
Porcine reproductive and respiratory syndrome virus (PRRSV) is known to interfere with the signaling of type I interferons (IFNs). Here we found PRRSV A2MC2 induced type I IFNs in cultured cells. A2MC2 replication in MARC-145 cells resulted in the synthesis of IFN-α2 protein, transcript elevation of the IFN-stimulated genes ISG15 and ISG56, and the proteins of the signal transducer and activator of transcription 2 (STAT2) and ISG56. A2MC2 infection of primary porcine pulmonary alveolar… CONTINUE READING
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