Induction of type I interferon by adenovirus-encoded small RNAs.

  title={Induction of type I interferon by adenovirus-encoded small RNAs.},
  author={Tomoko Yamaguchi and Kenji Kawabata and Emi Kouyama and Ken J Ishii and Kazufumi Katayama and Takayuki Suzuki and Shinnosuke Kurachi and Fuminori Sakurai and Shizuo Akira and Hiroyuki Mizuguchi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 40},
Transduction with replication-incompetent recombinant adenovirus (Ad) vectors results in a rapid activation of innate immune responses, such as inflammatory cytokine production and subsequent tissue damage. The precise mechanisms of the innate immune responses induced by Ad vectors remain to be clarified. Possible components of Ad vectors that activate innate immune responses are the capsid protein, the viral genome (DNA), and viral transcripts. In the present study, we demonstrate that virus… CONTINUE READING