Induction of type I diabetes by Kilham's rat virus in diabetes-resistant BB/Wor rats.

@article{Guberski1991InductionOT,
  title={Induction of type I diabetes by Kilham's rat virus in diabetes-resistant BB/Wor rats.},
  author={Dennis L. Guberski and Valerie A Thomas and William R. Shek and Arthur A. Like and Eugene S. Handler and Aldo A. Rossini and John M.D. Ed Wallace and Raymond M. Welsh},
  journal={Science},
  year={1991},
  volume={254 5034},
  pages={
          1010-3
        }
}
Type I diabetes mellitus is an autoimmune disease resulting from the interaction of genetic and environmental factors. A virus that was identified serologically as Kilham's rat virus (KRV) was isolated from a spontaneously diabetic rat and reproducibly induced diabetes in naive diabetes-resistant (DR) BB/Wor rats. Viral antigen was not identified in pancreatic islet cells, and beta cell cytolysis was not observed until after the appearance of lymphocytic insulitis. KRV did not induce diabetes… CONTINUE READING
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