Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids.

@article{Uberti1998InductionOT,
  title={Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids.},
  author={Daniela Letizia Uberti and Marco Belloni and Mariagrazia Grilli and PierFranco Spano and Maurizio Memo},
  journal={The European journal of neuroscience},
  year={1998},
  volume={10 1},
  pages={
          246-54
        }
}
We found that primary cultures of rat cerebellar granule cells, although definitely postmitotic and terminally differentiated, express the tumour-suppressor phosphoprotein p53. In particular, granule cells both expressed significant levels of p53 mRNA and positively reacted to an anti-p53 antibody, from the first day of culturing. During neurone differentiation, p53 mRNA content did not significantly change, at least up to 12 days in vitro, while p53 immunoreactivity increased gradually. p53… CONTINUE READING
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