Induction of tumoricidal activated macrophages by a liposome-encapsulated glycolipid, trehalose 2,3,6'-trimycolate from Gordona aurantiaca.

@article{Furukawa1990InductionOT,
  title={Induction of tumoricidal activated macrophages by a liposome-encapsulated glycolipid, trehalose 2,3,6'-trimycolate from Gordona aurantiaca.},
  author={M. Furukawa and Y. Ohtsubo and N. Sugimoto and Y. Katoh and Y. Dohi},
  journal={FEMS microbiology immunology},
  year={1990},
  volume={2 2},
  pages={
          83-8
        }
}
  • M. Furukawa, Y. Ohtsubo, +2 authors Y. Dohi
  • Published 1990
  • Biology, Medicine
  • FEMS microbiology immunology
  • A mycolic acid-containing glycolipid, trehalose 2,3,6'-trimycolate, prepared from a non-pathogenic acid-fast bacterium Gordona aurantiaca, was shown to induce strong tumoricidal activity in peritoneal exudate cells by intravenous or intraperitoneal injection of liposome-encapsulated preparations. The mycolic acid derivative containing a high proportion of unsaturated fatty acids rendered macrophages cytotoxic against syngeneic mastocytoma cells in the absence of endotoxin, for over 14 days… CONTINUE READING
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