Induction of tumor necrosis factor- alpha secretion and toll-like receptor 2 and 4 mRNA expression by genital mucosal fluids from women with bacterial vaginosis.

@article{Zariffard2005InductionOT,
  title={Induction of tumor necrosis factor- alpha secretion and toll-like receptor 2 and 4 mRNA expression by genital mucosal fluids from women with bacterial vaginosis.},
  author={Mohammadreza Zariffard and Richard M Novak and Nell S. Lurain and Beverly E. Sha and Parrie J Graham and Gregory T. Spear},
  journal={The Journal of infectious diseases},
  year={2005},
  volume={191 11},
  pages={1913-21}
}
BACKGROUND Bacterial vaginosis (BV) is associated with complications of pregnancy and increased susceptibility to human immunodeficiency virus (HIV) sexual transmission. METHODS The ability of genital mucosal fluids from women with BV and of microbial flora associated with BV to induce tumor necrosis factor (TNF)- alpha secretion and Toll-like receptor (TLR) 2 and TLR4 mRNA expression was assessed. RESULTS Primary peripheral-blood mononuclear cells and THP-1 monocytic cells secreted TNF… CONTINUE READING