Induction of tumor necrosis factor-alpha release by lipopolysaccharide and defined lipopolysaccharide partial structures.

@article{Feist1989InductionOT,
  title={Induction of tumor necrosis factor-alpha release by lipopolysaccharide and defined lipopolysaccharide partial structures.},
  author={W. Feist and Artur J. Ulmer and J Musehold and Helmut Brade and Shoichi Kusumoto and H. D. Flad},
  journal={Immunobiology},
  year={1989},
  volume={179 4-5},
  pages={293-307}
}
We have investigated the release of tumor necrosis factor-alpha (TNF-alpha) by human mononuclear cells (MNC) and isolated human monocytes/macrophages stimulated with S- and R-form lipopolysaccharide (LPS), natural lipid A, and natural and synthetic partial structures thereof. We found that LPS of Salmonella minnesota (S. min.) Rb2, which represents a partial structure of wildtype LPS of Salmonella abortus equi (S.a.e.) lacking the O-chain and parts of the outer core region, was the most active… CONTINUE READING

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