Induction of tumor immunity and cytotoxic T lymphocyte responses using dendritic cells transfected with messenger RNA amplified from tumor cells.

@article{Boczkowski2000InductionOT,
  title={Induction of tumor immunity and cytotoxic T lymphocyte responses using dendritic cells transfected with messenger RNA amplified from tumor cells.},
  author={David Boczkowski and Smita K Nair and Jong Hee Nam and H Kim Lyerly and Eli Gilboa},
  journal={Cancer research},
  year={2000},
  volume={60 4},
  pages={1028-34}
}
Unique patient-specific tumor antigens may constitute the dominant antigens in the antitumor immune response. Hence, vaccination with the patient's own repertoire of tumor antigens may offer a superior strategy to elicit protective immunity. We have shown previously that dendritic cells transfected with mRNA isolated from tumor cells stimulate potent CTL responses and engender protective immunity in tumor-bearing mice. In the current study, we demonstrate that tumor mRNA, isolated from murine… CONTINUE READING