Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody.

@article{Pearson1992InductionOT,
  title={Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody.},
  author={Thomas C. Pearson and Joren C. Madsen and Christian P Larsen and Peter J. Morris and Kathryn J. Wood},
  journal={Transplantation},
  year={1992},
  volume={54 3},
  pages={475-83}
}
The T-cell-mediated immune response usually results in the rapid destruction of organ allografts transplanted between murine strains incompatible for major and minor histocompatibility antigens. This response may be modified by pretreatment with either donor-specific antigen or anti-CD4 monoclonal antibody. Previous work by others has shown that combined treatment of mice with soluble protein antigens and anti-CD4 monoclonal antibody can produce antigen-specific B cell unresponsiveness that… CONTINUE READING

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