Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins.

@article{Missero1991InductionOT,
  title={Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins.},
  author={C Missero and Ellen Filvaroff and Gian Paolo Dotto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 8},
  pages={3489-93}
}
Transforming growth factors beta (TGF-beta s) are potent inhibitors of epithelial cell growth in culture and might play a similar role in vivo. Several studies have suggested that acquisition of TGF-beta resistance is an important step in epithelial tumor development. Here, we show that resistance to TGF-beta 1 growth inhibition can be induced by transformation of keratinocytes with the E1A, but not the ras, oncogene. Mutational analysis revealed that these effects closely correlate with the… CONTINUE READING
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