Induction of transcriptional activity of the cyclic adenosine monophosphate response element binding protein by parathyroid hormone and epidermal growth factor in osteoblastic cells.

@article{Swarthout2002InductionOT,
  title={Induction of transcriptional activity of the cyclic adenosine monophosphate response element binding protein by parathyroid hormone and epidermal growth factor in osteoblastic cells.},
  author={J. Todd Swarthout and Darren R Tyson and Stephen C Jefcoat and Nicola C Partridge},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2002},
  volume={17 8},
  pages={1401-7}
}
Previously, we have shown that parathyroid hormone (PTH) transactivation of cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) requires both serine 129 (S129) and serine 133 (S133) in rat osteosarcoma cells UMR 106-01 (UMR) cells. Furthermore, although protein kinase A (PKA) is responsible for phosphorylation at S133, glycogen synthase kinase 3beta (GSK-3beta) activity is required and may be responsible for phosphorylation of CREB at S129. Here, we show, using the… CONTINUE READING
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