Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification.

@article{Yuki2013InductionOT,
  title={Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification.},
  author={Yoshikazu Yuki and Mio Mejima and Shiho Kurokawa and Tomoko Hiroiwa and Yuko Takahashi and Daisuke Tokuhara and Tomonori Nochi and Yuko Katakai and Masaharu Kuroda and Natsumi Takeyama and Koji Kashima and Michiyo Abe and Yingju Chen and Ushio Nakanishi and Takehiro Masumura and Yoji Takeuchi and Hiroko Kozuka-Hata and Hiroaki Shibata and Masaaki Oyama and Kunisuke Tanaka and Hiroshi Kiyono},
  journal={Plant biotechnology journal},
  year={2013},
  volume={11 7},
  pages={
          799-808
        }
}
Plants have been used as expression systems for a number of vaccines. However, the expression of vaccines in plants sometimes results in unexpected modification of the vaccines by N-terminal blocking and sugar-chain attachment. Although MucoRice-CTB was thought to be the first cold-chain-free and unpurified oral vaccine, the molecular heterogeneity of MucoRice-CTB, together with plant-based sugar modifications of the CTB protein, has made it difficult to assess immunological activity of vaccine… CONTINUE READING
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