Induction of tolerance to self MHC class I molecules expressed under the control of milk protein or beta-globin gene promoters.

@article{Sponaas1994InductionOT,
  title={Induction of tolerance to self MHC class I molecules expressed under the control of milk protein or beta-globin gene promoters.},
  author={A M Sponaas and Peter D. Tomlinson and John Antoniou and Nathalie Auphan and Christelle Langlet and Bernard Malissen and A. M. Schmitt-Verhulst and Andrew L Mellor},
  journal={International immunology},
  year={1994},
  volume={6 2},
  pages={277-87}
}
We have studied tolerance induction in transgenic CBA mice expressing H-2Kb genes under the influence of guinea-pig alpha-lactalbumin (KAL) or human beta-globin gene promoter (K beta). KAL radio-resistant cells, but not bone marrow derived cells, induce tolerance to H-2Kb in chimeric mice. In contrast, bone marrow derived and radio-resistant cells of K beta mice induce tolerance. Although appropriate, tissue-specific, expression of H-2Kb molecules occurs in KAL and K beta mice, H-2Kb is… CONTINUE READING

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