Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells.

@article{Battaglia2006InductionOT,
  title={Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells.},
  author={Manuela Battaglia and Angela Stabilini and Elena Draghici and Barbara Migliavacca and Silvia Gregori and Ezio Bonifacio and Maria Grazia Roncarolo},
  journal={Diabetes},
  year={2006},
  volume={55 6},
  pages={1571-80}
}
Success in developing novel therapies to recommence self-tolerance in autoimmunity depends on the induction of T regulatory (Tr) cells. Here, we report that rapamycin combined with interleukin (IL)-10 efficiently blocks type 1 diabetes development and induces long-term immunotolerance in the absence of chronic immunosuppression in nonobese diabetic (NOD) mice. Rapamycin mediates accumulation in the pancreas of suppressive CD4(+)CD25(+)FoxP3(+) Tr cells, which prevent diabetes. IL-10 induces Tr… CONTINUE READING
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