Induction of tolerance by exosomes and short-term immunosuppression in a fully MHC-mismatched rat cardiac allograft model.

@article{Pche2006InductionOT,
  title={Induction of tolerance by exosomes and short-term immunosuppression in a fully MHC-mismatched rat cardiac allograft model.},
  author={H{\'e}l{\`e}ne P{\^e}che and Karine Renaudin and Ga{\"e}lle B{\'e}riou and Emmanuel M{\'e}rieau and S{\'e}bastian Amigorena and Maria Cristina Cuturi},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2006},
  volume={6 7},
  pages={1541-50}
}
Exosomes are MHC-bearing vesicles secreted by a wide array of cells. We have previously shown that donor-haplotype exosomes from bone marrow dendritic cells (DCs) injected before transplantation significantly prolong heart allograft survival in congenic and fully MHC-mismatched Lewis rats. Here we show that donor exosomes administered after transplantation are similarly able to prolong allograft survival, however, without inducing tolerance. We therefore tested the effect of exosomes combined… CONTINUE READING