Induction of thyroid gene expression and radioiodine uptake in thyroid cancer cells by targeting major signaling pathways.

@article{Hou2010InductionOT,
  title={Induction of thyroid gene expression and radioiodine uptake in thyroid cancer cells by targeting major signaling pathways.},
  author={Peng Hou and Ermal Bojdani and Michael Xing},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2010},
  volume={95 2},
  pages={
          820-8
        }
}
CONTEXT Radioiodine ablation is commonly used to treat thyroid cancer, but a major challenge is often the loss of radioiodine avidity of the cancer caused by aberrant silencing of iodide-handling genes. OBJECTIVES This study was conducted to test the therapeutic potential of targeting the aberrantly activated MAPK and PI3K/Akt/mTOR pathways and histone deacetylase to restore radioiodine avidity in thyroid cancer cells. EXPERIMENTAL DESIGN We tested the effects of specific inhibitors… CONTINUE READING
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Radioiodine refractory differentiated thyroid cancer.

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  • 2018
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