Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines.

@article{Chu1991InductionOT,
  title={Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines.},
  author={Eleanor Chu and James C. Drake and Dr. rer. nat. M. K{\"o}ller and Sydelle Zinn and Carlos A. Jamis-Dow and Grace Chao Yeh and Carmen Joseph Allegra},
  journal={Molecular pharmacology},
  year={1991},
  volume={39 2},
  pages={136-43}
}
A series of Adriamycin-resistant human breast MCF-7 and human colon DLD-1 cancer cell lines were established by stepwise selection. The concentration of Adriamycin required to inhibit cell proliferation by 50% (IC50) in the parent breast line (MCF-7), Adriamycin-resistant lines (MCF-Ad5 and MCF-Ad10), and a 5-fluorouracil (5-FU)-revertant line (MCF-R) was 0.005, 3.3, 6, and 4.9 microM, respectively. The Adriamycin IC50 value for the resistant colon line (DLD-Ad) was 8.2 microM, 68-fold higher… CONTINUE READING
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