Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling.

Abstract

Zebrafish cyclops (cyc) mutations cause deficiencies in the dorsal mesendoderm and ventral neural tube, leading to neural defects and cyclopia. Here we report that cyc encodes a transforming growth factor-beta (TGF-beta)-related intercellular signalling molecule that is similar to mouse nodal. cyc is expressed in dorsal mesendoderm at gastrulation and in… (More)

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Cite this paper

@article{Sampath1998InductionOT, title={Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling.}, author={Kartik Sampath and Aviad Rubinstein and Albert Mo Kim Cheng and Jinlong Liang and K Fekany and Lilianna Solnica-Krezel and Vladimir Korzh and Marnie E Halpern and Christopher V E Wright}, journal={Nature}, year={1998}, volume={395 6698}, pages={185-9} }