Induction of the stress response increases interleukin-6 production in the intestinal mucosa of endotoxaemic mice.

@article{Wang2000InductionOT,
  title={Induction of the stress response increases interleukin-6 production in the intestinal mucosa of endotoxaemic mice.},
  author={Quan Wang and Xiaoyan Sun and Timothy A. Pritts and Hector R Wong and Per Olof Hasselgren},
  journal={Clinical science},
  year={2000},
  volume={99 6},
  pages={489-96}
}
Previous studies suggest that production of interleukin-6 (IL-6) is increased in the intestinal mucosa during sepsis and endotoxaemia. We tested the hypothesis that mucosal IL-6 production during endotoxaemia is increased further by the heat-shock (stress) response. The stress response was induced in mice by hyperthermia (rectal temperature of 42 degrees C for 3 min) or by intraperitoneal injection of sodium arsenite (10 mg/kg). At 2 h after induction of the stress response, groups of mice were… CONTINUE READING