Induction of the photoaging-associated mitochondrial common deletion in vivo in normal human skin.

@article{Berneburg2004InductionOT,
  title={Induction of the photoaging-associated mitochondrial common deletion in vivo in normal human skin.},
  author={Mark 10 Berneburg and Heidi Plettenberg and Kathrin Medve-K{\"o}nig and Annette B. Pfahlberg and Heiner Gers-Barlag and Olaf Gefeller and Jean Krutmann},
  journal={The Journal of investigative dermatology},
  year={2004},
  volume={122 5},
  pages={1277-83}
}
Mutations of mitochondrial (mt) DNA such as the 4977 base-pair large-scale deletion, also called common deletion, are increased in photoaged skin. Direct evidence for their induction by chronic exposure to ultraviolet (UV) radiation in vivo in human skin has remained elusive however. Furthermore, their fate after induction is unclear. Previously unirradiated skin of 52 normal human individuals was repetitively exposed to physiological doses of UVA light. Skin and blood specimens were… CONTINUE READING

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