Induction of the multixenobiotic/multidrug resistance system in HeLa cells in response to imidazolium ionic liquids.

The multixenobiotic/multidrug resistance (MXR/MDR) system controls transport of foreign molecules across the plasma membrane as a preventive measure before toxicity becomes apparent. The system consists of an efflux pump, ABCB1, and/or a member of the ABCC family. Ionic liquids are broadly used solvents with several unique properties such as wide liquid… CONTINUE READING