Induction of the mouse kappa-opioid receptor gene by retinoic acid in P19 cells.

@article{Li2002InductionOT,
  title={Induction of the mouse kappa-opioid receptor gene by retinoic acid in P19 cells.},
  author={Jinhua Li and Sung Wook Park and Horace H. Loh and L N Wei},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 42},
  pages={39967-72}
}
The mouse kappa-opioid receptor (KOR) gene is expressed in mouse embryonal carcinoma P19 cells and induced by retinoic acid (RA) within 24 h. An RA-responsive cis-acting element is identified within promoter I of the KOR gene. This element contains a GC box, a putative binding site for transcription factor Sp1. Enhanced binding of Sp1 to this GC box correlates with RA induction of KOR gene. Phosphatase inhibitor (sodium pyrophosphate) decreases RA induction of this promoter, whereas… CONTINUE READING