Induction of the metabolism of etizolam by carbamazepine in humans

  title={Induction of the metabolism of etizolam by carbamazepine in humans},
  author={S. Kondo and T. Fukasawa and N. Yasui-Furukori and T. Aoshima and A. Suzuki and Y. Inoue and T. Tateishi and K. Otani},
  journal={European Journal of Clinical Pharmacology},
  • S. Kondo, T. Fukasawa, +5 authors K. Otani
  • Published 2005
  • Chemistry, Medicine
  • European Journal of Clinical Pharmacology
  • ObjectiveTo examine the effect of carbamazepine on the single oral dose pharmacokinetics of etizolam.MethodsEleven healthy male volunteers received carbamazepine 200 mg/day or placebo for 6 days in a double-blind, randomized, crossover manner, and on the sixth day they received a single oral 1-mg dose of etizolam. Blood samplings and evaluation of psychomotor function by the Digit Symbol Substitution Test and Stanford Sleepiness Scale were conducted up to 24 h after etizolam dosing. Plasma… CONTINUE READING
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