Induction of the male-specific cytochrome P450 3A2 in female rats by phenytoin.

@article{Ghosal1996InductionOT,
  title={Induction of the male-specific cytochrome P450 3A2 in female rats by phenytoin.},
  author={A. Ghosal and Nakissa Sadrieh and Linda M. Reik and Wayne Levin and Paul E. Thomas},
  journal={Archives of biochemistry and biophysics},
  year={1996},
  volume={332 1},
  pages={153-62}
}
We previously reported that administration of dexamethasone (DEX) and other selected pharmacological agents to rats resulted in a profound increase in hepatic cytochrome P450 3A1 in both sexes, but male constitutive P450 3A2 was modestly increased (4-fold) in adult males and not detected in either treated or untreated females (Cooper et al., Arch. Biochem. Biophys. 301, 345, 1993). Using a more sensitive Western blot stain, we have now detected in females low but significant induction of P450… CONTINUE READING

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