Induction of the lung myofibroblast PDGF receptor system by urban ambient particles from Mexico City.

@article{Bonner1998InductionOT,
  title={Induction of the lung myofibroblast PDGF receptor system by urban ambient particles from Mexico City.},
  author={James C. Bonner and Annette B. Rice and Pamela M. Lindroos and Peter O'Brien and Kevin L. Dreher and Irma Rosas and Ernesto Alfaro-Moreno and A R Osornio-Vargas},
  journal={American journal of respiratory cell and molecular biology},
  year={1998},
  volume={19 4},
  pages={672-80}
}
Platelet-derived growth factor (PDGF) and its receptor system regulate mesenchymal cell proliferation. We recently reported that emission-source fly-ash particles and asbestos fibers induce the PDGF alpha-receptor through a macrophage-dependent pathway, and upregulation of this receptor greatly enhances the mitogenic response of lung myofibroblasts to PDGF… CONTINUE READING