Induction of the lac promoter in the absence of DNA loops and the stoichiometry of induction

@article{Oehler2006InductionOT,
  title={Induction of the lac promoter in the absence of DNA loops and the stoichiometry of induction},
  author={Stefan Oehler and Siegfried Alberti and Benno M{\"u}ller-Hill},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={606 - 612}
}
In vivo induction of the Escherichia coli lactose operon as a function of inducer concentration generates a sigmoidal curve, indicating a non-linear response. Suggested explanations for this dependence include a 2:1 inducer-repressor stoichiometry of induction, which is the currently accepted view. It is, however, known for decades that, in vitro, operator binding as a function of inducer concentration is not sigmoidal. This discrepancy between in vivo and in vitro data has so far not been… CONTINUE READING

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Genetic analysis of the leucine heptad repeats of Lac repressor: evidence for a 4-helical bundle

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