Induction of the ganglion cell differentiation program in human retinal progenitors before cell cycle exit.

@article{Pacal2014InductionOT,
  title={Induction of the ganglion cell differentiation program in human retinal progenitors before cell cycle exit.},
  author={Marek Pacal and Rod Bremner},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2014},
  volume={243 5},
  pages={
          712-29
        }
}
BACKGROUND Despite the disease relevance, understanding of human retinal development lags behind that of other species. We compared the kinetics of gene silencing or induction during ganglion cell development in human and murine retina. RESULTS Induction of POU4F2 (BRN3B) marks ganglion cell commitment, and we detected this factor in S-phase progenitors that had already silenced Cyclin D1 and VSX2 (CHX10). This feature was conserved in human and mouse retina, and the fraction of Pou4f2… CONTINUE READING
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